Figure 3. Kir4.1-tdTomato mice given TMX at post-weaning stages exhibit tdTom expression in TPSC of the diaphragm as well as in some cells of the phrenic nerve.
A, Low-magnification images of the diaphragm muscle from P50 Kir4.1-tdTomato mice given TMX from P30-P43 show tdTom+ TPSC at AlexaFluor 488-conjugated α-BTX-labeled AChR clusters (arrowhead), but also in cells associated with phrenic nerve (arrow). B, Diaphragm muscle from P25 Kir4.1-tdTomato mice given TMX from P9-P22 shows tdTomato expression (red) by two Hoechst-labeled nuclei (arrows, purple) near AlexaFluor 488-conjugated α-BTX-labeled AChR clusters (green) in the left and middle panel. Percentage of TPSC at α-BTX-labeled NMJ expressing tdTom in the diaphragm and EDL muscles after TMX from P30-P43 (right panel); data in text.