Substance use disorder polygenic risk score (PRS) primary associations. (A) Forest plot showing odds ratios and 95% confidence intervals for associations between each PRS and the primary DSM-IV and DSM-5 diagnosis in African (AFR) individuals (left) and European (EUR) individuals (right). (B) Stacked bar plot showing the number and type of phenotypes involving the same substance associated with each PRS. AUD, alcohol use disorder; CAN, lifetime cannabis use; OR, odds ratio; OUD, opioid use disorder; SMK, smoking initiation.