Table 1.

Demographic and Clinical Features

Ancestry	DSM-IV Diagnosis								DSM-5 Diagnosis
	Tobacco Dependence		Alcohol Dependence		Opioid Dependence		Cannabis Dependence		Alcohol Use Disorder		Opioid Use Disorder		Cannabis Use Disorder
	n (% Female)	Age, Mean ± SD	n (% Female)	Age, Mean ± SD	n (% Female)	Age, Mean ± SD	n (% Female)	Age, Mean ± SD	n (% Female)	Age, Mean ± SD	n (% Female)	Age, Mean ± SD	n (% Female)	Age, Mean ± SD
African
Cases	2679 (40.2%)	42.2 ± 9.2	2631 (35.7%)	42.0 ± 9.6	938 (35.4%)	44.5 ± 8.7	1402 (28.5%)	40.3 ± 9.8	3215 (36.3%)	41.7 ± 9.6	1014 (34.9%)	44.5 ± 8.7	2082 (30.7%)	40.7 ± 9.7
Controls	1534 (57.3%)	39.1 ± 11.6	1470 (64.2%)	40.7 ± 11.4	3848 (47.9%)	40.5 ± 10.4	2532 (56.0%)	41.7 ± 10.6	1395 (65.4%)	40.6 ± 11.5	3839 (48.0%)	40.5 ± 10.4	2376 (58.2%)	41.7 ± 10.7
European
Cases	3156 (37.7%)	38.4 ± 11.6	2945 (34.1%)	39.1 ± 11.6	2276 (34.7%)	36.5 ± 10.4	1628 (28.7%)	35.1 ± 10.7	3669 (34.5%)	38.6 ± 11.7	2394 (34.2%)	36.5 ± 10.5	2416 (28.7%)	36.2 ± 11.1
Controls	1983 (54.5%)	42.9 ± 14.7	1813 (61.2%)	42.0 ± 15.0	3246 (51.0%)	42.1 ± 14.2	3082 (55.1 %)	42.5 ± 13.8	1617 (62.6%)	42.8 ± 15.1	3213 (51.3%)	42.1 ± 14.2	2846 (57.1%)	42.7 ± 14.0