Fig. 3. Non-necroptotic RIPK3 signaling prevents clearance of chronic LCMV at late stages of infection.

Virus titres in mice with the indicated genotypes, across various organs at indicated timepoints postinfection with LCMV docile. Viral loads were titred in the A lung, B liver, C spleen, D kidney and E brain. Each symbol represents one mouse. Dotted line indicates the reliable limit of detection (LOD) for the assay. The median is indicated by a horizontal line in each group at each time point. *p < 0.05, **p < 0.01, ***p < 0.005 (one-way ANOVA followed by Dunnett’s multiple comparisons test).