Table 3.
Multivariable Cox-regression analyses for survival
| Multivariable-PFS | Multivariable-DSS | Multivariable-OS | |||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | CI [95%] | p value | HR | CI [95%] | p value | HR | CI [95%] | p value | |
| Histopathological tumor characteristics | |||||||||
| Tumor stage (TNM) | n/a | 0.84 | 0.42–1.68 | 0.612 | 1.08 | 0.66–1.78 | 0.757 | ||
| FIGO stage | 1.72 | 1.19–2.50 | 0.004 | 2.52 | 1.68–3.78 | < 0.001 | 1.98 | 1.45–2.71 | < 0.001 |
| Histological subtype | n/a | 2.93 | 0.62–13.89 | 0.177 | 2.14 | 0.63–7.26 | 0.221 | ||
| Histological grading | 1.51 | 0.84–2.72 | 0.168 | 1.74 | 0.84–3.59 | 0.135 | 1.47 | 0.85–2.56 | 0.173 |
| Postoperative residual tumor burden | 1.38 | 0.53–3.62 | 0.510 | 1.21 | 0.51–2.89 | 0.671 | 0.94 | 0.35–2.51 | 0.898 |
| Anamnestic life style parameter | |||||||||
| Mean age | n/a | n/a | n/a | ||||||
| Smoking status | n/a | n/a | n/a | ||||||
| Physical performance | n/a | n/a | n/a | ||||||
| Cognitive functioning | n/a | n/a | n/a | ||||||
| Global health status assessment tools | |||||||||
| G8 Score | 2.01 | 0.87–4.65 | 0.102 | 4.58 | 1.35–15.51 | 0.015 | 2.89 | 1.31–6.39 | 0.009 |
| Lee-index | 1.12 | 0.68–1.86 | 0.654 | n/a | 1.12 | 0.69–1.81 | 0.644 | ||
| CCI | n/a | 1.23 | 0.50–3.02 | 0.647 | 1.50 | 0.77–2.95 | 0.234 | ||
| ASA PS | n/a | n/a | 1.35 | 0.51–3.54 | 0.545 | ||||
Bold values indicate significant results (p < 0.05)
Italic values indicate clinically relevant results (p < 0.1)
PFS progression-free survival, DSS disease-specific survival, OS overall survival, HR hazard ratio, CI confidence interval, TNM-FIGO tumor staging system-international federation of gynecology and obstetrics, G8 Score G8 geriatric screening tool, Lee-Index Lee-Schonberg prognostic index, CCI Charlson comorbidity index, ASA PS American society of anesthesiologists physical status system, n/a not applicable (excluded because not significant values in univariate Cox-regression analysis)