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. 2023 Jan 19;25(3):90. doi: 10.3892/ol.2023.13676

Figure 2.

Figure 2.

Effect of si-HIF-1α on the proliferation, invasion and ferroptosis of NSCLC cells. Results of (A) Cell Counting Kit-8, (B) flow cytometry and (C) Transwell invasion assays of NSCLC cells transfected with si-HIF-1α. (D) Levels of ROS, MDA, Fe2+ and GSH in A549 cells transfected with si-HIF-1α. Scale bar, 50 µm. (E) Protein expression of GPX4 in A549 cells transfected with si-HIF-1α. *P<0.05, **P<0.01 and ***P<0.001 vs. si-NC. si-HIF-1α, small interfering RNA to hypoxia-inducible factor 1α; NSCLC, non-small cell lung cancer; ROS, reactive oxygen species; MDA, malondialdehyde; Fe2+, ferrous iron; GSH, glutathione; GPX4, glutathione peroxidase 4; si-NC, small interfering RNA negative control; OD, optical density.