TABLE 1.
Echocardiographic parameters in different groups of mice.
| C57 | ApoE–/– | ||||
| Parameters | NC (n = 8) | WI + NC (n = 8) | WI + HFD (n = 8) | HFD (n = 8) | WI + HFD (n = 8) |
| BW before (g) | 20.71 ± 0.2943 | 21.56 ± 0.1614 | 20.86 ± 0.1592 | 19.50 ± 0.2570 | 20.19 ± 0.5252 |
| BW after (g) | 26.90 ± 0.3808 | 27.39 ± 0.6572 | 30.30 ± 0.8842 | 26.45 ± 0.5892 | 28.78 ± 1.034 |
| Heart rate (bpm.) | 481.9 ± 11.55 | 499.7 ± 5.173 | 508.6 ± 6.495 | 509.0 ± 5.015 | 509.2 ± 6.308 |
| CO (ml/min) | 16.70 ± 1.581 | 20.39 ± 1.132 | 19.43 ± 1.751 | 18.09 ± 1.137 | 19.25 ± 1.347 |
| SV (ml) | 34.71 ± 3.167 | 40.81 ± 2.374 | 38.12 ± 3.279 | 35.50 ± 2.116 | 38.33 ± 2.622 |
| IVSd (mm) | 0.7603 ± 0.04889 | 0.8153 ± 0.03333 | 0.7750 ± 0.03417 | 0.7870 ± 0.06187 | 0.8323 ± 0.03092 |
| PWd (mm) | 0.6346 ± 0.04637 | 0.5645 ± 0.03125 | 0.5553 ± 0.02830 | 0.5803 ± 0.03770 | 0.6162 ± 0.03277 |
| LVEDd (mm) | 3.524 ± 0.09762 | 3.703 ± 0.1638 | 3.831 ± 0.1431 | 3.676 ± 0.09880 | 3.734 ± 0.1219 |
| EF (%) | 65.96 ± 3.742 | 71.13 ± 4.002 | 59.91 ± 3.067 | 62.43 ± 3.604 | 70.64 ± 1.270 |
| FS (%) | 36.14 ± 2.792 | 40.83 ± 3.599 | 31.67 ± 2.117 | 33.47 ± 2.505 | 39.38 ± 1.103 |
| Transaortic peak velocity (mm/s) | 1010 ± 80.15 | 1790 ± 58.66*** | 1753 ± 139.8 | 1152 ± 29.14 | 2261 ± 117.6##‡ |
| AVA (mm2) | 0.8100 ± 0.04265 | 0.5489 ± 0.04154*** | 0.5406 ± 0.03140 | 0.8679 ± 0.04904 | 0.3855 ± 0.01797#‡ |
Data are presented as mean ± SEM. NC, normal chow; HFD, high-fat diet; WI, wire injury; AVA, aortic valve area; BW, body weight; FS, function of shortening; IVSd, intraventricular septal diameter; LVEDd, left ventricular end-diastolic diameter; PWd, posterior wall diameter.
***P < 0.001 vs. C57 + NC, #P < 0.05 vs. C57 + WI + HFD, ##P < 0.01 vs. C57 + WI + HFD, ‡P < 0.001 vs. ApoE–/–+ HFD.