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. 2023 Feb 2;14:1087011. doi: 10.3389/fneur.2023.1087011

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Copyright © 2023 Aychman, Goldman and Kaplan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A summary of CBD's actions in TBI. CBD has numerous actions that are proposed to protect against secondary injury and support recovery from TBI. These actions include effects on numerous neurotransmitter systems that increase levels of brain derived neurotrophic factor and enhance neurogenesis, dampen inflammatory signaling cascades, scavenge for reactive oxygen and nitrogen species (ROS and RNS, respectively), restore the integrity of the blood brain barrier, improve control over cerebral blood flow, and attenuate inflammatory and neuropathic pain.