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. 2023 Feb 16;14:863. doi: 10.1038/s41467-023-36595-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a–f The wild-type and Nsun2^cKO mice were treated with 3% DSS in drinking water. Nsun2^cKO mice injected with recombinant mouse-IL-17A (rIL-17A) (500 ng/mouse) or IL-17F (rIL-17F) (500 ng/mouse) alone, or both rIL-17A (500 ng/mouse) and rIL-17F (500 ng/mouse) once every other day. Four mice were used in each group. Body weight changes (a), representative macrograph of spleens (b) and colons (c), the colon length (n = 4 per group) (d), hematoxylin-eosin staining indicated the severity of colons damage and inflammatory infiltration (Scale bar, 100 μm) (e), and colitis score (n = 4 per group) (f). P values are calculated by using two-tailed unpaired Student’s t-test (a, d, f). All data are representative of two independent experiments. Error bars represent mean ± s.e.m. Source data are provided as a Source Data file.