Fig. 6. Nsun2 deletion alleviates colitis development by breaking cell-cell communication between Th17 cells and IL-17 receptors-expressing cells.
a UMAP plots of the major clusters. Each point depicts a single cell, colored according to cell types. b The chart showing the number and percentage of cell type. c UMAP plots showing the different cell types across the three kind of mice colon samples, which respectively under WT + H2O (left), WT + DSS (middle) and Nsun2cKO + DSS (right) treatment. The rescued up-regulated cell types were marked in red dash line circles, and the rescued downregulated cell types were marked in green dash line circles. d UMAP plots showing expression of IL-17 receptors for rescued cell types. Source data are provided in Supplementary Data 4.