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In vivo pharmacodynamic assessment. The knee joint histopathology was evaluated using (A) H&E -stained and (B) Toluidine blue stained (n = 6). (C) Micro-CT pictures of the keen joints after treatments. (D) Quantitative micro-CT analysis of BMD, (E) trabecular number (Tb. N), and (F) trabecular separation (Tb. Sp) (n = 6). Values are mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.
