TABLE 4.

Summary of clinical chemistry, hematology and hormone parameters assessed in main group males in the repeat-dose 90-day toxicity study. *Statistically significant (p < 0.05) with respect to the vehicle group.

Dose (mg/kg b.w.)	Vehicle 0		Paraxanthine - 100		Paraxanthine - 150		Paraxanthine - 185		Caffeine - 150		Caffeine - 185
	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD
ALT (U/L)	46.5	8.34	68.70*	17.99	58.2	12.15	64.10*	12.63	65.80*	10.5	69.56*	12.76
AST (U/L)	75.7	11.05	182.20*	80.74	124.60*	33.94	92.00	7.51	118.10*	13.77	113.11*	16.77
Ca (mg/dL)	9.69	0.23	8.68*	0.53	9.50	0.44	9.72	0.28	9.33	0.66	9.43	0.54
Cholesterol (mg/dL)	56.6	10.63	58.20	10.43	57.9	9.28	60.3	8.92	73.20*	17.83	74.11*	13.19
Creatinine (mg/dL)	0.24	0.05	0.22	0.07	0.12*	0.04	0.16*	0.07	0.23	0.05	0.34*	0.07
GGT (U/L)	5.30	1.06	4.80	1.32	4.10*	0.57	4.30	0.82	4.20	1.48	5.11	1.05
Phosphorus (mg/dL)	5.39	0.28	5.90*	0.5	6.27*	0.44	6.33*	0.36	6.51*	0.52	6.11*	0.85
Triglycerides (mg/dL)	55.70	23.2	46.00	16.46	28.10*	9.64	32.10*	8.06	28.90*	10.47	24.22*	6.04
HDL (mg/dL)	52.2	9.9	54.00	7.16	53.00	7.64	57.60	7.18	67.90*	13.67	70.56*	11.65
LDL (mg/dL)	8.50	1.18	10.20	1.93	12.50*	3.34	10.50	1.84	12.90*	2.92	13.44*	1.88
Na+ (mmol/L)	136.45	1.86	136.43	1.83	136.09	1.4	136.22	1	134.60*	1.36	135.1	0.82
K+ (mmol/L)	4.4	0.14	4.38	0.35	4.73	0.42	4.6	0.41	4.58*	0.2	4.31	0.15
Cl- (mmol/L)	104.56	1.21	104.76	1.19	104.95	0.5	105.28	0.89	103.12*	0.87	102.29*	1.66
T3	5.3	1.3	6.6	1.8	6.9	1.8	9.8*	2.7	7.5*	1.5	8.7*	1.1
T4	230.8	47.2	204.5	36.9	177.8*	36.2	173.9*	32.1	188.2*	21.4	181.7*	13.9
WBC (10 3 cells/µL)	9.32	2.13	9.85	2.53	10.86	1.99	9.98	1.78	10.45	2.01	11.65*	1.46
RBC (10 6 cells/µL)	9.56	0.35	9.22	0.71	9.48	0.36	9.58	0.39	9.08*	0.3	9.29	0.55
MCV (fL)	56.38	1.23	57.25	1.7	58.38*	1.43	58.35*	1.43	58.39	2.74	57.89	1.66
MCH (pg)	16.72	0.38	16.86	0.95	16.96	0.81	17.47	0.41	17.43*	0.86	17.34	0.41