TABLE 7.

Summary of absolute organ weights for females in the repeat-dose 90-day toxicity study. Values represent mean ± SD. *Statistically significant (p < 0.05) with respect to the vehicle group.

Dose (mg/kg b.w.)	Vehicle 0	Paraxanthine - 100	Paraxanthine - 150	Paraxanthine - 185	Caffeine - 150	Caffeine - 185
Adrenals	0.07334 ± 0.01640	0.08343 ± 0.01597	0.09413 ± 0.02217*	0.0744 ± 0.01500	0.08975 ± 0.01423	0.09303 ± 0.01822
Thymus	0.37544 ± 0.10322	0.32814 ± 0.04639	0.28995 ± 0.07156	0.30999 ± 0.06019	0.27308 ± 0.05827*	0.26947 ± 0.07063*
Spleen	0.62254 ± 0.10870	0.60117 ± 0.07442	0.57166 ± 0.08149	0.54832 ± 0.03470	0.56087 ± 0.04883	0.55137 ± 0.09321
Heart	1.084 ± 0.34130	1.12372 ± 0.11596	1.16994 ± 0.09185	1.1161 ± 0.06957	1.13286 ± 0.08331	1.14708 ± 0.10927
Brain	2.06603 ± 0.08983	2.10052 ± 0.09091	2.00639 ± 0.08111	2.08486 ± 0.07586	1.99639 ± 0.09944	1.94498 ± 0.07350*
Kidneys	2.17679 ± 0.23112	2.24008 ± 0.21491	2.10597 ± 0.14674	2.06906 ± 0.23927	2.33549 ± 0.19490	2.09417 ± 0.23091
Liver	10.84485 ± 1.58733	10.92884 ± 1.22639	10.68754 ± 1.01925	10.04758 ± 0.76868	10.85476 ± 0.62288	10.60714 ± 0.98894
Ovaries	0.15894 ± 0.02590	0.18028 ± 0.04256	0.19807 ± 0.03636	0.13956 ± 0.04787	0.17346 ± 0.04719	0.15929 ± 0.03259
Uterus with cervix	1.0486 ± 0.36606	0.72098 0.23428	0.69851 ± 0.17391	0.83874 ± 0.32582	0.77222 ± 0.25966	0.68401 ± 0.28696
Pituitary	0.02182 ± 0.00468	0.02260 ± 0.0058	0.02017 ± 0.00248	0.02183 ± 0.00439	0.02064 ± 0.00428	0.01763 ± 0.00515
Thyroid & Parathyroid	0.03343 ± 0.00667	0.02438 ± 0.00500	0.02560 ± 0.00677	0.02766 ± 0.00588	0.02599 ± 0.00587	0.03154 ± 0.00987