TABLE 8.

Summary of absolute organ weights for recovery group males and females in the repeat-dose 90-day toxicity study. Values represent mean ± SD. *Statistically significant (p < 0.05) with respect to the vehicle group.

Dose (mg/kg b.w.)	Vehicle 0 recovery (males)	Paraxanthine—185 recovery (males)	Caffeine– 185 recovery (males)	Vehicle 0) recovery (females)	Paraxanthine—185 recovery (females)	Caffeine– 185 recovery (females)
Adrenals	0.05552 ± 0.00744	0.07106 ± 0.01002*	0.06319 ± 0.00318	0.06627 ± 0.01083	0.0689 ± 0.01499	0.07309 ± 0.00835
Thymus	0.34461 ± 0.09950	0.3429 ± 0.05200	0.31459 ± 0.09923	0.27167 ± 0.10157	0.32416 ± 0.06561	0.29798 ± 0.05752
Spleen	0.84257 ± 0.16616	1.02084 ± 0.10001	0.74054 ± 0.16568	0.52665 ± 0.03057	0.55206 ± 0.05684	0.55663 ± 0.09083
Heart	1.71727 ± 0.17712	1.98022 ± 0.12241*	1.62546 ± 0.16916	1.06126 ± 0.03013	1.15511 ± 0.14457	1.03703 ± 0.04720
Brain	2.22603 ± 0.19378	2.16304 ± 0.09426	2.10495 ± 0.09495	2.06947 ± 0.09111	2.00996 ± 0.09472	1.93851 ± 0.10298
Kidneys	3.52317 ± 0.23260	4.05760 ± 0.20928*	3.19812 ± 0.50449	2.05429 ± 0.14511	2.07322 ± 0.27388	1.87379 ± 0.03797*
Liver	15.4413 ± 1.82498	16.7718 ± 1.16758	11.68069 ± 1.81996*	8.83301 ± 1.09478	9.87243 ± 1.36150	7.83365 ± 0.70018
Testes	3.48985 ± 0.30427	3.8643 ± 0.27753	3.59449 ± 0.33402	n/a	n/a	n/a
Epididymides	1.51534 ± 0.16365	1.60369 ± 0.08125	1.44345 ± 0.12122	n/a	n/a	n/a
PSVC	3.7983	3.24068*	3.22433	n/a	n/a	n/a
Thyroid and parathyroid	0.034 ± 0.00814	0.03344 ± 0.00217	0.03036 ± 0.00493	0.02939 ± 0.00847	0.03114 ± 0.00981	0.02293 ± 0.00443
Pituitary	0.02050 ± 0.00425	0.02279 ± 0.00251	0.01523 ± 0.00149*	0.02069 ± 0.00136	0.02933 ± 0.00801*	0.02027 ± 0.00193
Ovaries	n/a	n/a	n/a	0.16256 ± 0.02231	0.12835 ± 0.02348*	0.16897 ± 0.00657
Uterus with cervix	n/a	n/a	n/a	0.85348 ± 0.33820	0.92171 ± 0.17938	0.69884 ± 0.09278