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. 2022 Oct 18;29(4):697–704. doi: 10.1158/1078-0432.CCR-22-0028

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©2022 The Authors; Published by the American Association for Cancer Research

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Figure 3. Orchestration of the T-cell synapse centers around the native TCR that binds to the target cell pHLA in a canonical fashion. TCR TCEs are designed to recreate this optimized synapse, including binding conformation, geometry, and distance (A). Antibody TCE binds surface proteins and may not recreate the canonical T-cell synapse (B). — Orchestration of the T-cell synapse centers around the native TCR that binds to the target cell pHLA in a canonical fashion. TCR TCEs are designed to recreate this optimized synapse, including binding conformation, geometry, and distance (A). Antibody TCE binds surface proteins and may not recreate the canonical T-cell synapse (B).