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. 2022 Dec 7;29(4):754–763. doi: 10.1158/1078-0432.CCR-22-1983

Figure 3.

Figure 3. Tremelimumab exposure-ORR analysis at Cmin1 (exposure–response analysis population); N = 208. Open blue circles reflect the observed events. Filled black circles are the observed probability of ORR and the error bars are the standard errors (calculated as sqrt [P*(1 − P)/n], where P is probability of response and n is the number of patients in each quantile bin) for quantiles [at 100 × (1/5)th percentiles, vertical dotted lines] of exposures (plotted at the median value within each quantile). The red lines are smooth curves (loess) to show the relationship between two variables. Cmin1, minimum tremelimumab concentration at day 28; N, number of patients included in the analysis.

Tremelimumab exposure-ORR analysis at Cmin1 (exposure–response analysis population); N = 208. Open blue circles reflect the observed events. Filled black circles are the observed probability of ORR and the error bars are the standard errors (calculated as sqrt [P*(1 − P)/n], where P is probability of response and n is the number of patients in each quantile bin) for quantiles [at 100 × (1/5)th percentiles, vertical dotted lines] of exposures (plotted at the median value within each quantile). The red lines are smooth curves (loess) to show the relationship between two variables. Cmin1, minimum tremelimumab concentration at day 28; N, number of patients included in the analysis. ORR, objective response rate.