Table 1.
General characteristics of studies exploring pediatric sibling donors of HSCT.
| Author | Country | Sample size (transplant status) | Study design | Measures |
|---|---|---|---|---|
| D’Auria et al. (2015) | Canada | 8 sibling donors aged 10–30 years (successful) | Qualitative, grounded theory | Semi-structured, open-ended interviews |
| Erden et al. (2019) | Turkey | 30 HSCT recipients; 20 donors aged 6–18 years; 30 nondonors aged 6–18 years | Cross-sectional study, descriptive, quantitative | Kiddie Schedule for Affective Disorders and
Schizophrenia (K-SADS) Children’s Depression Inventory State-Trait Anxiety Inventory for Children State-Trait Anxiety Inventory Rosenberg Self-Esteem Scale Hollingshead-Redlich Scale |
| Gizli Coban et al. (2017) | Turkey | 35 mothers and siblings (donor and nondonor)
aged 5–18 years; 35 healthy peers aged 5–18 years and mothers |
Cross-sectional study, descriptive, quantitative | CPTSD-RI PCL-C (mothers) PedsQL 4.0 |
| Hoag et al. (2018) | USA | 9 sibling donors aged 9–21 years (6 successful; 3 unsuccessful) | Mixed methods, longitudinal study | Semi-structured
interview The Child Behavior Checklist (ages 6–18) Youth Self-Report (ages 11–18) Adult Self-Report (age 18–59) The Ways of Coping Questionnaire The Network of Relationships Inventory The Faces of Pain Scale Revised |
| Hutt et al. (2015) | Israel | 36 sibling donors median age 13 at time of donation, 50 parents of pediatric patients | Cross-sectional, descriptive, quantitative | Questionnaires: Donor’s attitude questionnaire regarding stem cell transplant Parent’s attitude questionnaire regarding the sibling donor experience |
| MacLeod et al. (2003) | Canada | 15 sibling donors aged 7–20 years (8 successful; 7 unsuccessful) | Qualitative, grounded theory | Interviews |
| Packman et al. (1997a; 1997b, 1998, 2003, 2004) | USA | 44 siblings; 21 donors, 23 nondonors aged 6–18 years (all successful) | Mixed methods with a cross-sectional description component | Semi-structured, forced-choice and open-ended
interviews using: The Revised Children’s Manifest Anxiety Scale The Child Depression Inventory The Rosenberg Self-Esteem Scale Child Post-Traumatic Stress Reaction Scale; Kinetic Family Drawing Revised Human Figure Drawing |
| Pelletier et al. (2014) | USA and Canada | 58 parents and surrogates; 19 patients; 16 donor siblings aged 9–17 years; 39 nondonor siblings, half-siblings and cousins | Qualitative, exploratory study (semantic content analysis); secondary analysis | Semi-structured, open-ended interviews |
| Pentz et al. (2014) | USA and Canada | T1= 12 sibling donors T2= 12 sibling donors T3= 10 sibling donors aged 9–18 years |
Mixed methods, cross-sectional description component | Interviews The Satisfaction with Decision Scale Decision Regret Scale |
| Pentz et al. (2012) | USA and Canada | 15 patients aged 11–18 years; 22 mothers; 2 step-mothers; 1 grandmother; 19 fathers; 3 stepfathers; 1 grandfather; 13 sibling donors aged 9–17 years; nondonor siblings aged 9–22 years | Qualitative grounded theory; secondary analysis | Qualitative Interviews |
| Pot-Mees and Zeitlin (1987) | England | 15 patients; 9 sibling donors; 10 sibling nondonors; 15 mothers; 8 fathers | Mixed methods, cross-sectional, pilot study | Semi-structured interview The Richmond BCL Rutter A Scale Ruth Griffiths Developmental Scales (younger children) British Abilities Scales (older children) General Health Questionnaire (parents) |
| Stegenga et al. (2019) | USA and Canada | 47 parents and surrogates; 17 patients; 16 donor siblings; 39 nondonor siblings; half-siblings; cousins | Qualitative, exploratory study (semantic content analysis); secondary analysis | Semi-structured, open-ended interviews |
| Switzer et al. (2016) | USA | 105 pediatric
donors: 5–7 years= 19; 8–12 years= 45; 13–18 years= 41 |
Quantitative, longitudinal | The Pediatric Quality of Life Inventory Health Related Quality of Life Open-ended question (parents) |
| White et al. (2017) | USA and Canada | 109 family members 56 parent/surrogates; 18 patients; 24 nondonor siblings; 11 donor siblings; 15 health care providers |
Qualitative, exploratory study (semantic content analysis); secondary analysis | Semi-structured, open-ended interviews |
| Wiener et al. (2008) | USA | 14 sibling donors: 11 siblings living (3 recipients deceased) aged 9–28 years | Qualitative, exploratory study (content analysis) | Retrospective interviews |
| Wilkins and Woodgate (2007) | Canada | 8 siblings: 3 donors; 5 nondonors (all recipients living) aged 11–24 years | Qualitative, hermeneutic phenomenology | Semi-structured, open-ended interviews |
| Zajac-Spychala et al. (2020) | Poland | 45 recipients median age 11.9 at time of donation; 45 sibling donors median age 15.5 at time of donation | Mixed methods, cross-sectional | Demographic
Survey Functional Assessment of Chronic Illness Therapy-Bone Marrow Transplant Functional Assessment of Cancer Therapy (FACT) (general) FACT T01 Adult Siblings Relationship Questionnaire |