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. 2023 Jan 6;299(2):102878. doi: 10.1016/j.jbc.2023.102878

Figure 2.

Figure 2

P53 is dispensable in pancreas organogenesis. Representative images of pancreas, stomach, spleen, and duodenum at birth (A, scale bar represents 250 pixels). Quantitative PCR of neonatal pancreas showing reduced p53 mRNA expression in the p53 knockout (B, n = 3). Body weight (C, n = 19–60), pancreas weight (D, n = 19–60), random blood glucose (E, n = 19–60), and serum insulin (F, n = 6), β-cell mass (G, n = 4–7), and α-cell mass (H, n = 4–7) at birth. Representative images of whole pancreas (I, large panel 10× magnification, scale bar represents 500 μm; inset 40× magnification, scale bar represents 50 μm; areas outside dotted lines indicate space added from canvas size adjustment) and islets showing normal morphology (J, 40× magnification, scale bar represents 50 μm) and Pdx1 localization (K, 40× magnification, scale bar represents 50 μm). Statistics conducted using one-way ANOVA followed by unpaired Student t test with Welch’s correction, p ≤ 0.05 deemed significant. ∗p < 0.05.