Fig. 3.

Post-reperfusion treatment with GSSSG prevented paraplegia after spinal cord ischemia in male and female mice. Changes in BMS scores for 72 h after SCI in male and female mice subjected to a sham surgical procedure, or SCI and treated with GSSSG, GSH, or vehicle alone. n = 11 for each of the GSSSG, GSH, and vehicle alone treatments in the male mouse cohort, and n = 8 for each of the GSSSG, GSH, and vehicle alone treatments in the female mouse cohort. n = 5 mice for the sham surgical group. Data are presented as means with standard deviation.

Abbreviations: BMS, Basso mouse scale for locomotion; GSH, glutathione; GSSSG, glutathione trisulfide; SCI, spinal cord ischemia.