Fig. 2.

SEC of (A) mouse plasma at low (L—), medium (M—), and high (H—) AAV_SOF doses. B: SEC of 250 μl HDL (1 mg/ml) after incubation with plasma (5 μl) from mice receiving L-, M-, and H-dose AAV_SOF. Gray-fill, HDL. C: Plasma total cholesterol 14 days after M-AAV_SOF dosing. ∗P < 0.05. D: PCR analysis of multiple tissues using primers for SOF, LDLR, and GAPDH as labeled for WT mice, Scarb1^-/- mice not treated with AAV_SOF (NT SKO), and Scarb1^-/- mice treated with AAV_SOF (SOF SKO). SEC, size-exclusion chromatography; SOF, serum opacity factor.