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. 2023 Feb 2;14:1057394. doi: 10.3389/fphys.2023.1057394

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Copyright © 2023 Hanly, Johnston, Lemass, Jose, Tornifoglio and Lally.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Qualitative and quantitative comparison of MicroCT to histology (A) Qualitative comparison observing the overall structure of porcine carotid arteries. (B) Region of interest selection for quantitative comparison of the collagen content observed in porcine carotid arteries. (C) Increase in collagen content observed in different sections of vessel wall whereby the external media present higher collagen content and HU then the internal media, internal (circles) and external (stars) regions of interest in the media. (D) Pearson correlation between HU from MicroCT and collagen content from PS-Red images when normalised with respect to volume.