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. 2023 Feb 2;14:1095555. doi: 10.3389/fmicb.2023.1095555

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Copyright © 2023 Yu, Chen, Liu, Meng, Liu, Yao, Song, Ren and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram depicting the pathogenic role and therapeutic potential of Lactobacillus reuteri in CRC. H1R, type 1 histamine receptor; H2R, type 2 histamine receptor; hdc, histidine decarboxylase; PLC, phospholipase C; PIP2, phosphatidylinositol 2; Dgk, diacylglycerol kinase; DAG, diacylglycerol; PA, phosphatidic acid; IP3, inositol triphosphate; PKC, protein kinase C; pPKC, phosphorylated protein kinase C; ER, endoplasmic reticulum; AhR, aryl hydrocarbon receptor; PKA, protein kinase A; pPKA, phosphorylated protein kinase A; KC, keratinocyte chemoattractant; ROS, reactive oxygen species; GSH, glutathione; LTV1, LTV1 ribosome biogenesis factor; RIOK2, right open reading frame kinase 2; YEATS2, YEATS domain-containing protein 2.