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. 2023 Jan 14;6:100446. doi: 10.1016/j.crfs.2023.100446

Table 3.

Bioactive peptide sequences and their interactions with potential DPP-IV binding sites.

Peptide sequence Mw Pepsite 2 (p value) a Binding residues in peptide Bound residues of DPP-Ⅳ
F4
FR 322.19 0.005277 F1, R2 Tyr48, Trp627, Trp629b, Gly741, Tyr752
WR 361.20 0.005748 W1, R2 Tyr48, Trp627, Trp629b, Tyr752
FGNWR 679.33 0.005428 G2, N3, W4, R5 Tyr48, Trp627, Trp629b, His740b, Gly741, ILe742, Ala743, His748, Tyr752
MFK 425.22 0.003096 M1, F2, K3 Tyr48, Trp627, Trp629b, Gly741, Tyr752
SFGPR 562.29 0.01877 G3, P4, R5 Phe357b, Tyr547b, Pro550, Trp659b, Tyr662b, Asp663, Tyr666b, Thr667, Tyr670
NPPFK 601.32 0.0003259 P2, P3, F4, K5 Glu206b, Phe357b, Tyr547b, Pro550, Tyr662b, Tyr666b, Tyr670
CPPSPR 655.31 0.1198 C1, P5, R6 Phe357b, Tyr547b, Pro550, Trp629b, Tyr666b, Tyr670, Tyr752
DFR 436.21 0.02662 D1, F2, R3 Tyr48, Trp627, Trp629b, His740b, Gly741, ILe742, Ala743, Tyr752
FNFSR 669.32 0.007846 F1, N2, F3, R5 Phe357b, Tyr547b, Pro550, Tyr631b, Trp659b, Tyr662b, Asp663, Tyr666b, Thr667, Tyr670
LFFSR 668.36 0.0174 L1, F2, F3, R5 Tyr48, Val546, Trp627, Gly628, Trp629b, Ser630b, His740b, Gly741, Ile742, Ala743, Tyr752
GFPSR 562.29 0.001407 F2, P3, S4, R5 Tyr48, Trp627, Trp629b, His740b, Gly741, Ile742, Ala743, Tyr752
FK 293.17 0.00525 F1, K2 Tyr48, Trp627, Trp629b, Gly741, Tyr752
MR 305.15 0.00785 M1, R2 Trp629b, Ser630b, Gly741, Tyr752
FFNSR 669.32 0.005675 F2, N3, S4, R5 Tyr48, Trp627, Trp629b, His740b, Gly741, ILe742, Ala743, Tyr752
WPDAR 643.31 0.01173 W1, D3, A4, R5 Tyr48, Trp627, Trp629b, His740b, Gly741, ILe742, Ala743, His748, Tyr752
LSGFPR 675.37 0.02638 L1, F4, P5, R6 Phe357b, Val546, Tyr547b, Pro550, Trp627, Gly628, Trp629b, Ser630b, Tyr631b, Trp659b, Tyr662b, Asp663, Tyr666b, Thr667, Tyr670
QFLR 562.32 0.0202 Q1, F2, L3 Tyr48, Trp627, Trp629b, Ser630b, Val653, Tyr752
FLK 406.26 0.00615 F1, L2, K3 Tyr48, Trp627, Trp629b, Tyr752
AFPYK 624.33 0.0008243 A1, F2, P3, Y4 Tyr48, Val546, Trp627, Gly628, Trp629b, Ser630b, Gly741, Tyr752
F6
FFK 440.24 0.003712 F1, F2, K3 Tyr48, Trp627, Trp629b, Gly741, Tyr752
SFR 408.21 0.009356 S1, F2, R3 Tyr48, Trp627, Trp629b, Tyr752
CPPTPR 669.33 0.08718 T4, P5, R6 Tyr48, Trp627, Trp629b, Tyr752

Note:

a

Binding site analysis by Pepsite 2 software (http://pepsite2.russelllab.org/).

b

Binding residues on the DPP-IV active sites.