FIGURE 6.

Projected ²²⁵Ac demand versus current ²²⁵Ac production via ²²⁹Th production from ²²³U legacy waste and potential future production. Current ²²⁵Ac production is estimated to be 55–65 GBq per year, which is inadequate even for current demand from researchers. Demand is projected to increase by 200–400 GBq per year for each ²²⁵Ac-based therapy that is approved for clinical use. Should efforts to develop ²¹³Bi-based therapies also increase, ²²⁵Ac demand may be even higher, highlighting the importance of new production methods to increase ²²⁵Ac supply to meet increasing demand. However, it should be noted that estimates of both demand and future production capacity vary widely.