Figure 5.

Summary of blood-based Bonferroni-significant functional genes and regulatory elements associated with both members of BCT-NPD trait pairs with significant genome-wide genetic correlations and significant local genetic correlations (but negligible genome-wide genetic correlations)

(A and D) Association of gene expression with each member of the focal BCT-NPD pair. (B and E) Association of DNA methylation with expression of trait-pair-associated genes. (C and F) Association of DNA methylation with BCT-NPD pairs. The width of each line represents the SMR association strength. Line color indicates whether up-regulation or down-regulation of functional genes (or DNA methylation levels) is associated with increased disorder risk or BCT values. See Tables S43 and S44 for complete details of the SMR estimates.