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. 2023 Feb 2;17:1123797. doi: 10.3389/fnins.2023.1123797

FIGURE 4.

FIGURE 4

(A,B,D–F) Correlation between abnormal amygdala RSFC at baseline and the remission rate of depressive symptoms and suicidal symptoms after ketamine treatment and ROC curve analysis. (C) Neuroimaging predictors of treatment non-response, with the non-responders defined with <50% improvements in HAMD-17 obtained after the ketamine infusions. The area under the ROC curve was 0.689 (p = 0.043) for the RSFC of the LA – right putamen, with a sensitivity of 91.4%, and specificity of 59.1%; the area under the ROC curve was 0.726 (p = 0.016) for RA – right putamen connectivity, with a sensitivity of 82.4%, and specificity of 68.2%; and the area under the ROC curve was 0.739 (p = 0.011) for LA – right putamen connectivity and RA-right putamen connectivity, with a sensitivity of 75.0%, and specificity of 73.7%. (G) Non-responders defined with <50% improvements SSI-5 score obtained after the ketamine infusions. The area under the ROC curve was 0.799 (p = 0.003) for the RSFC of the LA – right putamen, with a sensitivity of 77.8%, and specificity of 83.3%; the area under the ROC curve was 0.787 (p = 0.005) for the RA – right putamen connectivity, with a sensitivity of 59.3%, and specificity of 91.7%; and the area under the ROC curve was 0.827 (p = 0.001) for LA – right putamen connectivity and RA – right putamen connectivity, with a sensitivity of 74.1%, and specificity of 83.3%. AUC, area under curve; LA, left amygdala; RA, right amygdala.