Table 2.

Odds of pathogenicity per ACMG/AMP classification

Classification	Threshold for odds of pathogenicity
Benign	(−∞, 0.001)
Likely Benign	[0.001, 1/18.07)
Uncertain significance	[1/18.07, 18.07]
Likely Pathogenic	(18.07, 100]
Pathogenic	(100, +∞)

Abbreviations: ACMG: American College of Medical Genetics; AMP: Association for Molecular Pathology.