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. 2022 Dec 12;30(3):559–569. doi: 10.1093/jamia/ocac242

Figure 2.

Figure 2.

Risk of bias of the included studies. The figure presents the risk of bias in the included studies, evaluated using the Cochrane Risk of Bias tool (ROB 2) for randomized controlled trials (top panel) and the Risk Of Bias In Nonrandomized Studies of Interventions (ROBINS-I) for nonrandomized controlled trials (bottom panel). Four (57%) randomized controlled trials were at high risk of bias and the nonrandomized controlled trial was at serious risk of bias. There were some concerns for the remaining randomized controlled trials.