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. 2023 Feb 16;11(2):e782. doi: 10.1002/iid3.782

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© 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Treatment of GA reduced matrix metallopeptidases overexpression in the ankle joints in the mouse model of arthritis induced by collagen. (A–C) The mRNA levels of MMP3 (A), MMP9 (B), and MMP13 (C) in ankle joint were determined by qPCR. (D) Besides, the protein expressions of MMP3, MMP9, and MMP13 were determined by using Western blot analysis. (E–G) The relative expressions were normalized to the internal control (n = 3; Eight tissue homogenates were mixed). *p < .05, **p < .01, and ***p < .001 as compared to the control. ^# p < .05, ^## p < .01, ^### p < .001 as compared to the CIA group. GAH corresponded to the GA administration dosage of 80 mg/kg/d.