Table 3. Binding Energies of Compounds 1–7 against iNOS (PDB ID: 4NOS), TNF-α (PDB ID: 1TNF), TACE (PDB ID: 3KME), and IKK (PDB ID: 4KIK).

compound	binding energy (kcal/mol)
	iNOS	TNF-α	TACE	IKK
1	–9.0	–8.4	–8.5	–10.2
2	–8.4	–8.3	–9.3	–9.8
3	–10.0	–5.2	–8.2	–10.7
4	–8.9	–8.4	–8.7	–9.5
5	–10.0	–6.1	–8.3	–10.4
6	–7.5	–7.0	–6.8	–7.5
7	–7.1	–7.9	–7.7	–6.9
tilarginine	–6.5
pentoxifylline		–8.6
apratastat			–6.8
MLN120B				–9.6