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. 2023 Jan 31;8(6):5157–5168. doi: 10.1021/acsomega.2c06567

Table 4. Completed Prospective Studies of Exosomes as Biomarkers for Various Types of Cancer Registered on ClinicalTrials.gov.

ClinicalTrials.gov ID cancer type and setting objectives primary outcome measures
NCT02702856 prostate cancer determine the association of an exosome urine test score with the presence of high Gleason grade/score (GS >/= 7) prostate cancer on a prostate needle biopsy correlate an exosome gene expression signature with the presence or absence of high grade prostate cancer in the prostate needle biopsy
NCT03830619 lung cancer investigate the sensitivity and specificity of serum exosome noncoding RNA as a biomarker for the diagnosis of lung cancer the expression levels of serum exosome long noncoding RNA
the expression levels of tumor biomarkers
the CT scans of the lung for the patients
NCT03895216 bone metastases obtain a panel of biomarkers predictive of bone metastasis changes in miRNAs content of circulating tumor exosomes
changes in protein content of circulating tumor exosomes
NCT03032913 pancreatic cancer determining whether liquid biopsy approaches are valid in the diagnosis of pancreatic cancer sensitivity of CTC detection with 3 methods in cell spiking experiments
diagnostic accuracy of the best CTC detection method and onco-exosome quantification for pancreatic adenocarcinoma diagnosis
NCT04720599 urologic cancer confirm the performance of the ExoDx prostate gene expression assay in patients presenting for an initial prostate biopsy correlation of the ExoDx prostate test results with the outcome of prostate biopsies in an initial biopsy patient cohort
NCT03911999 prostate cancer investigate the relationship of urinary exosome and the aggressiveness of prostate cancer differences in microRNA expression between nonprostate cancer subjects, pathologically insignificant, and significant prostate cancer patients
the accuracy of selected microRNAs for the differentiation of patients with pathologically insignificant and significant prostate cancer after radical prostatectomy
NCT03031418 prostate cancer a new and validated urine test which predicts the likelihood of high grade prostate cancer on an initial prostate biopsy confirm performance of the ExoDx Prostate IntelliScore
NCT02862470 thyroid cancer analyze the urine exosomal proteins and probable biological markers, then find the prognostic biological markers prognostic biological markers via this prospective study.
NCT05101655 lung metastasis of osteosarcoma use exosome microfluidic chips to establish a combination of exosome subgroup level (exosome barcode) markers for the early diagnosis of osteosarcoma lung recurrence the association of disease recurrence with plasma levels of exosome and its subgroups
NCT05334849 advanced gastric carcinoma verify the function of circulating exosomal lncRNA-GC1 on predicting and monitoring immunotherapeutic outcomes of GC levels of circulating exosomal lncRNA-GC1