Fig. 2.

Impairment of movement disorder after ischemic stroke elicited by CRM28 exposure. CRM28 was suspended in water and intranasally (i.n.) administered at doses of 0, 10 or 100 µg/mouse once a day for 7 days. Coordinated movement was measured by a rotarod test before (day 0) and 1, 3, 5 and 7 days after photothrombosis induction. The reported values are the mean ± S.D. (n = 8 animals in each group). The area under the curve (AUC) from 1 to 7 days was calculated, and the AUC was analyzed using one-way ANOVA [F(2, 21) = 8.363, p = 0.0021] followed by Dunnett’s multiple comparisons test. The p values of the vehicle versus 10 µg CRM groups and vehicle versus 100 µg CRM groups were 0.666 and 0.0018, respectively