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. 2023 Feb 16;27:63. doi: 10.1186/s13054-023-04344-6

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Complement factors in patients with sepsis. Violin plots of concentrations of the complement factors C3 (a), C3a (b), C3c (c), C5 (d), C5a (e), and sTCC (f) in plasma of patients with sepsis (n = 209) compared to healthy controls (n = 10). Data are presented as median with interquartile range on a log-scale. The P values in the panels were calculated with Mann–Whitney U tests. Heatmaps of the correlations between complement factors (g) and between the complement factors and inflammatory parameters (h). Correlation coefficients and P values were calculated with Spearman rank correlation tests. *Indicates P < 0.05 after Bonferroni correction for multiple testing. Abbreviations: HC, healthy controls; sTCC, soluble terminal complement complex; CRP, C-reactive protein