Table 1.
Patient demographics and clinical outcome parameters for quartiles of complement factors
| Quartile 1 (lowest) | Quartile 2 | Quartile 3 | Quartile 4 (highest) | P valueA | |
|---|---|---|---|---|---|
| C3 | |||||
| Age (years) | 76 (65–83) | 75 (60–83) | 74 (66–85) | 77 (68–86) | > 0.99 |
| Sex, male | 25 (49) | 29 (57) | 32 (63) | 30 (59) | > 0.99 |
| BMI (kg/m2) | 25.8 (21.0–31.1) | 26.8 (23.6–29.4) | 26.3 (22.0–31.1) | 26.0 (22.5–29.3) | > 0.99 |
| SOFA | 12 (9–16) | 12 (10–15) | 11 (8–13) | 10 (8–13) | 0.13 |
| Shock | 38 (75) | 43 (84) | 73 (75) | 33 (65) | 0.96 |
| 28-day mortality rate | 31 (61) | 38 (75) | 31 (61) | 24 (47) | 0.27 |
| C3a | |||||
| Age (years) | 81 (67–87) | 74 (65–81) | 75 (67–83) | 75 (62–81) | 0.47 |
| Sex, male | 26 (52) | 33 (66) | 28 (56) | 27 (54) | > 0.99 |
| BMI (kg/m2) | 26.1 (21.3–28.1) | 26.2 (22.2–29.1) | 26.3 (22.5–31.2) | 27.3 (23.9–31.1) | > 0.99 |
| SOFA | 12 (10–15) | 11 (7–14) | 11 (8–13) | 11 (9–13) | > 0.99 |
| Shock | 41 (82) | 36 (72) | 37 (74) | 33 (66) | > 0.99 |
| 28-day mortality rate | 36 (72) | 32 (64) | 23 (46) | 28 (56) | 0.32 |
| C3c | |||||
| Age (years) | 81 (68–88) | 78 (70–87) | 73 (63–81) | 74 (64–81) | 0.042 |
| Sex, male | 25 (51) | 31 (63) | 29 (59) | 25 (52) | > 0.99 |
| BMI (kg/m2) | 27.8 (22.7–31.2) | 24.4 (21.9–27.5) | 26.1 (23.2–29.4) | 27.7 (22.2–31.2) | > 0.99 |
| SOFA | 11 (9–15) | 11 (8–14) | 11 (8–13) | 11 (6–14) | > 0.99 |
| Shock | 44 (90) | 36 (74) | 36 (74) | 29 (60) | 0.066 |
| 28-day mortality rate | 34 (69) | 30 (61) | 31 (63) | 25 (52) | > 0.99 |
| C5 | |||||
| Age (years) | 77 (66–84) | 75 (67–86) | 77 (69–85) | 73 (60–82) | > 0.99 |
| Sex, male | 33 (64) | 30 (57) | 30 (58) | 26 (50) | > 0.99 |
| BMI (kg/m2) | 27.8 (24.0–31.1) | 23.8 (21.3–27.7) | 27.1 (24.1–29.6) | 26.8 (21.6–32.1) | 0.22 |
| SOFA | 11 (9–15) | 11 (7–14) | 11 (7–14) | 11 99–13) | > 0.99 |
| Shock | 45 (87) | 39 (74) | 37 (71) | 35 (67) | 0.75 |
| 28-day mortality rate | 34 (65) | 28 (53) | 34 (65) | 30 (58) | > 0.99 |
| C5a | |||||
| Age (years) | 78 (65–86) | 77 (67–86) | 72 (60–79) | 76 (66–84) | 0.66 |
| Sex, male | 32 (65) | 23 (49) | 33 (69) | 23 (49) | 0.53 |
| BMI (kg/m2) | 26.1 (21.2–29.4) | 27.3 (22.4–31.1) | 25.8 (22.5–29.4) | 27.8 (22.9–31.3) | > 0.99 |
| SOFA | 11 (10–14) | 11 (7–14) | 11 (8–12) | 12 (9–15) | > 0.99 |
| Shock | 41 (84) | 33 (70) | 36 (75) | 34 (72) | > 0.99 |
| 28-day mortality rate | 33 (67) | 27 (57) | 25 (52) | 32 (68) | > 0.99 |
| sTCC | |||||
| Age (years) | 81 (64–87) | 76 (69–83) | 76 (64–85) | 73 (62–79) | 0.66 |
| Sex, male | 30 (58) | 31 (59) | 26 (50) | 32 (62) | > 0.99 |
| BMI (kg/m2) | 26.3 (22.8–29.8) | 27.3 (22.9–29.4) | 26.2 (22.7–30.7) | 25.4 (20.8–33.0) | > 0.99 |
| SOFA | 11 (8–13) | 11 (9–15) | 11 (9–13) | 11 (8–15) | > 0.99 |
| Shock | 39 (75) | 39 (74) | 40 (77) | 38 (73) | > 0.99 |
| 28-day mortality rate | 30 (58) | 33 (62) | 33 (64) | 30 (58) | > 0.99 |
Data are presented as median (interquartile range) or n (%)
AP values are calculated with Kruskal–Wallis tests or Chi-square tests with Bonferroni correction for multiple testing
BMI body mass index, SOFA Sequential Organ Failure Assessment, sTCC soluble terminal complement complex