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. 2023 Feb 15;23:27. doi: 10.1186/s12935-023-02866-1

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — CCL14-AS is downregulated in CRC and associated with favorable prognosis. A The cancer-related, metastasis-related and survival-related lncRNAs were selected from the TCGA datasets. B Analysis of CCL14-AS expression in CRC compared with normal tissues in TCGA-COADREAD. C CCL14-AS expressions in paired CRC cancer tissues and adjacent normal tissues in TCGA-COADREAD were compared. D CCL14-AS expression in normal, N0 Stage CRC samples and N1-2 Stage CRC samples in TCGA-COADREAD was also compared. E Kaplan–Meier analysis of overall survival in all patients with CRC according to CCL14-AS expression in TCGA datasets (log-rank test P = 0.035). F qRT-PCR was performed to determine relative CCL14-AS RNA level in paired CRC cancer tissues and adjacent normal tissues. G–I FISH assay was conducted to determine the expression of CCL14-AS in 96 paraffin-embedded CRC tissues. G Representative FISH images are shown. CCL14-AS‑stained are green, DAPI‑stained nuclei are blue. Scale bar: 100 μm. H Graphical illustration of statistical CCL14-AS distribution in CRC patients. I Kaplan–Meier analysis of overall survival rate according to high, medium or low CCL14-AS expression. * p < 0.05, ** p < 0.01, *** p < 0.001