. 2023 Feb 16;18:17. doi: 10.1186/s13020-023-00716-w

Table 2.

Semi-quantitative statistics for the differential metabolites regulated by CF and four fractions

Metabolite name	Sample	Model/Control	CF/Model	SX/Model	CF30/Model	CF60/Model	CF90/Model	Allopurinol/Model	Pathway
Deoxyuridine	Plasma	0.5↓^**	1.3↑	1.2↑	1.2↑	1.3↑	2.1↑^**	1.2↑	c
Deoxycytidine	Plasma	0.6↓^**	1.2↑	1.1↑	1↑	1.1↑	1↑	1.2↑	c
Adenosine monophosphate	Plasma	1.9↑^*	0.6↓^*	0.7↓	0.8↓	0.5↓^*	0.7↓	0.7↓	a
Adenosine	Plasma	2.6↑^*	0.6↓	1.9↑	0.8↓	0.8↓	0.8↓	1.6↑	a
Cytidine	Plasma	0.6↓^*	1.1↑	1.3↑^*	1↓	1↓	1.2↑	1.2↑	c
L-Tyrosine	Plasma	0.6↓^**	1↑	1↓	1.1↑	0.9↓	0.9↓	1↓	d
L-Serine	Plasma	0.6↓^**	1↑	1.1↑	1.3↑^**	0.9↓	1.1↑	1↑	d
alpha-Ketoglutaric acid	Plasma	0.5↓^**	1.8↑^**	1.7↑^**	1.8↑^*	1.4↑	1.7↑^*	0.8↓	b
Ornithine	Plasma	0.6↓^*	1↑	1↓	1.2↑	0.9↓	1↓	1↑	b,e
Orotic acid	Plasma	5.3↑^**	0.9↓	1.1↑	1.1↑	1↓	0.8↓	0.8↓^*	c
Riboflavin	Plasma	1.5↑^**	0.8↓^*	0.8↓^*	0.9↓	0.7↓^**	0.8↓^*	0.8↓	f
Uric acid	Plasma	4.3↑^**	0.8↓^*	1↑	1.1↑	0.7↓^**	0.6↓^*	0.2↓^**	a
Urea	Plasma	1.3↑^*	0.8↓	0.9↓	1.1↑	0.9↓	1.1↑	1↓	a,b
Xanthosine	Plasma	0.5↓^**	1.2↑	0.9↓	1.1↑	1.1↑	1.4↑	3.1↑^**	a
Uracil	Plasma	5↑^**	0.9↓	0.9↓	1.2↑	0.7↓	0.8↓	0.6↓^*	c
N-Acetyl-L-phenylalanine	Plasma	2.3↑^*	0.7↓	0.7↓	0.4↓^*	0.7↓	0.7↓	1.3↑
L-Arginine	Plasma	0.6↓^**	1↓	1↓	1.2↑	0.9↓	1↓	1↓	b,d,e
L-Glutamine	Plasma	0.6↓^**	1.1↑	1.2↑	1.2↑^*	1.1↑	1.1↑	1.1↑	a,b,c,d,g
Indoxyl sulfate	Plasma	2.8↑^**	0.7↓	0.7↓	0.9↓	0.6↓^*	0.7↓	0.8↓
Kynurenic acid	Plasma	1.8↑^*	0.7↓	0.8↓	0.8↓	0.5↓^**	0.9↓	0.6↓^*
Indoleacetaldehyde	Plasma	0.6↓^*	0.8↓	1.2↑	0.9↓	1.2↑	1.3↑	1.3↑
Guanosine monophosphate	Plasma	1.7↑^*	0.5↓^*	0.6↓	0.7↓	0.5↓^*	0.7↓	1↓	a
Phosphocreatine	Plasma	0.6↓^*	1.3↑	1.1↑	1.5↑	0.9↓	1↓	0.9↓	e, g
Indoxyl glucuronide	Plasma	2.1↑^*	0.6↓^*	0.6↓^*	1.1↑	0.6↓^*	0.8↓	0.7↓	i
N-Acetylhistidine	Plasma	1.6↑^**	0.8↓	0.8↓	0.8↓	0.7↓^**	0.8↓	0.8↓
Deoxycytidine	Kidney	0.6↓^**	1↑	1↑	0.8↓	1↓	1↓	1.3↑	c
Carnosine	Kidney	0.5↓^*	1.7↑^*	1.5↑^**	1.8↑^**	1.6↑^*	1.3↑	1.2↑	h
β-Alanine	Kidney	0.6↓^**	1.5↑^*	1.3↑	1.7↑^*	1.3↑	1.3↑	1.2↑	c,h
SN-glycero-3-phosphocholine	Kidney	0.4↓^*	3.1↑^**	2.3↑^**	2.4↑^*	3.6↑^**	2.2↑^*	1.3↑
Hypoxanthine	Kidney	0.6↓^**	1.8↑^**	1.5↑^*	1.6↑^*	1.5↑^**	1↑	1.5↑^*	a
Inosine 5ʹ- monophosphate	Kidney	0.6↓^*	2.6↑^*	1.8↑	2.4↑	2.7↑^**	1.3↑	1.3↑	a
Inosine	Kidney	0.5↓^**	2↑^**	1.7↑^*	1.9↑^**	1.7↑^**	1.1↑	2.1↑^**	a
Orotic acid	Kidney	6.4↑^**	1.2↑	0.9↓	1.6↑^*	1.3↑	0.8↓	0.7↓	c
Succinic acid	Kidney	1.4↑^*	0.9↓	0.8↓	0.8↓	0.8↓^*	0.8↓^*	0.8↓
Uridine	Kidney	0.6↓^**	1.5↑^**	1.4↑	1.3↑^*	1.4↑^*	1↑	1.2↑	c
Adenosine 5ʹ-triphosphate	Kidney	0.6↓^**	1.5↑^*	1.1↑	1.4↑^*	1.6↑^*	1.2↑	1↓	a
Cytosine	Kidney	0.7↓^**	1.1↑	1.1↑	0.9↓	1↑	0.9↓	1.1↑	c
L-Glutamine	Kidney	0.7↓^*	1.1↑	1↑	0.9↓	1↑	1.2↑	1↑	a, c, e
Citrulline	Kidney	1.4↑^*	0.7↓^*	0.7↓^**	0.8↓	0.6↓^**	0.8↓	0.8↓	e
Betaine-Aldehyde	Kidney	2.4↑^**	0.4↓^**	0.7↓	0.4↓^**	0.4↓^**	0.8↓	0.4↓^**
Ribose 5-phosphate	Kidney	0.5↓^**	2.1↑^**	1.7↑	2.1↑^**	1.8↑^**	1.2↑	1.5↑^*	a
CDP-ethanolamine	Kidney	0.5↓^*	2.3↑^**	1.4↑	1.9↑^*	2.3↑^*	1.6↑	1↑
Phosphorylcholine	Kidney	0.4↓^*	2.7↑^**	2.4↑^**	2.4↑^*	3.5↑^**	2.1↑^*	1.3↑

a: purine metabolism

b: Arginine biosynthesis

c: Pyrimidine metabolism

d: Aminoacyl-tRNA biosynthesis

e: Arginine and proline metabolism

f: Riboflavin metabolism

g: Alanine, aspartate and glutamate metabolism

H: beta-Alanine metabolism

I: Pentose and glucuronate interconversions

*p < 0.05, **p < 0.01