. 2022 Oct 21;22(11):6504–6520. doi: 10.1021/acs.cgd.2c00722

Table 3. pK_aValues of PRM, MEL, and Salt Formers and Their ΔpK_a Values.

	pK_a in water	ΔpK_a for PRM	ΔpK_a for MEL	structure
PRM	1.86,^a 5.46²¹
MEL	1.09,^a 4.18²²
4AP	9.17⁷⁷	7.31	8.08	1:1 salt
4DMP	9.70⁷⁸	7.84	8.61	1:1 salt
PPZ	9.72⁷⁹	7.86	8.63	2:1 salt

It is the hydroxyl group that is deprotonated in this work.

Table 3. pKaValues of PRM, MEL, and Salt Formers and Their ΔpKa Values.