Table 3. IC50 Values of Compounds 7a–j against MCF-7 and HePG-2 Cell Lines.
| compound no. | R | X | IC50 in μg/mL MCF-7 | IC50 in μg/mL HePG-2 |
|---|---|---|---|---|
| doxorubicin | 4.17 ± 0.2 | 5.57 ± 0.4 | ||
| 7a | H | CN | 23.76 ± 1.9 | 26.84 ± 3.3 |
| 7b | Me | CN | 35.03 ± 2.3 | 30.42 ± 1.1 |
| 7c | OMe | CN | 29.43 ± 1.1 | 24.12 ± 2.9 |
| 7d | Cl | CN | 67.32 ± 3.7 | 73.05 ± 4.3 |
| 7e | Br | CN | 10.10 ± 2.1 | 9.11 ± 3.2 |
| 7f | H | COOEt | 15.90 ± 2.3 | 13.37 ± 1.2 |
| 7g | Me | COOEt | 12.30 ± 2.4 | 11.87 ± 2.7 |
| 7h | OMe | COOEt | 11.36 ± 1.5 | 12.18 ± 1.1 |
| 7i | Cl | COOEt | 10.08 ± 1.5 | 7.83 ± 2.1 |
| 7j | Br | COOEt | 11.80 ± 4.0 | 10.26 ± 4.8 |