Table 1.
Comparison of demographics and medical comorbidities in patients admitted with autoimmune hepatitis; male versus female
| Demographics | Prematch comparison | Postmatch comparison | ||||||||||
| Female | Male | P value | Univariate analysis | Female | Male | P value | Univariate analysis | |||||
| n=17 178 | 78.85% | n=4609 | 21.15% | OR (95% CI) | n=4609 | 50% | n=4609 | 50% | OR (95% CI) | |||
| Age (years) | 58.3 | ±17.60 years | 54.1 | ±18.30 years | <0.001*** | 54 | ±18.10 years | 54.1 | ±18.30 years | 0.7 | ||
| Race | <0.001*** | 0.65 | ||||||||||
| White (%) | 11 579 | 67.4 | 3347 | 72.6 | 3373 | 73.2 | 3347 | 72.6 | ||||
| Black (%) | 2981 | 17.4 | 707 | 15.3 | 675 | 14.6 | 707 | 15.3 | ||||
| Hispanic (%) | 2618 | 15.2 | 555 | 12 | 561 | 12.2 | 555 | 12 | ||||
| Comorbidities | ||||||||||||
| Diabetes (%) | 4678 | 27.2 | 1292 | 28 | 0.29 | 0.96 (0.89 to 1.03) | 1283 | 27.8 | 1292 | 28 | 0.85 | 0.99 (0.90 to 1.08) |
| Hyperlipidaemia (%) | 3750 | 21.8 | 994 | 21.6 | 0.72 | 1.02 (0.94 to 1.10) | 968 | 21 | 994 | 21.6 | 0.52 | 0.97 (0.88 to 1.07) |
| Hypertension (%) | 6397 | 37.2 | 1384 | 30 | <0.001*** | 1.38 (1.29 to 1.48) | 1380 | 29.9 | 1384 | 30 | 0.95 | 1 (0.91 to 1.09) |
| Chronic obstructive pulmonary disease (%) | 1726 | 10 | 370 | 8.03 | <0.001*** | 1.28 (1.14 to 1.44) | 319 | 6.92 | 370 | 8.03 | 0.05* | 0.85 (0.73 to 1.00) |
| Coronary artery disease (%) | 1908 | 11.1 | 719 | 15.6 | <0.001*** | 0.68 (0.62 to 0.74) | 670 | 14.5 | 719 | 15.6 | 0.16 | 0.92 (0.82 to 1.03) |
| Chronic kidney disease (%) | 2536 | 14.8 | 816 | 17.7 | <0.001*** | 0.81 (0.74 to 0.88) | 787 | 17.1 | 816 | 17.7 | 0.44 | 0.96 (0.86 to 1.07) |
| Congestive heart failure (%) | 2018 | 11.7 | 467 | 10.1 | 0.002** | 1.18 (1.06 to 1.31) | 393 | 8.53 | 467 | 10.1 | 0.009** | 0.83 (0.72 to 0.95) |
| Coagulopathies (%) | 769 | 4.48 | 227 | 4.93 | 0.21 | 0.9 (0.78 to 1.05) | 203 | 4.4 | 227 | 4.93 | 0.26 | 0.89 (0.73 to 1.08) |
| Smoking (%) | 4264 | 24.8 | 1387 | 30.1 | <0.001*** | 0.77 (0.71 to 0.82) | 1365 | 29.6 | 1387 | 30.1 | 0.63 | 0.98 (0.89 to 1.07) |
| Liver aetiologies | ||||||||||||
| Primary liver cancer (%) | 246 | 1.43 | 104 | 2.26 | <0.001*** | 0.63 (0.50 to 0.79) | 65 | 1.41 | 104 | 2.26 | 0.003** | 0.62 (0.45 to 0.85) |
| Hepatocellular carcinoma (%) | 225 | 1.31 | 86 | 1.87 | 0.006** | 0.7 (0.54 to 0.90) | 60 | 1.3 | 86 | 1.87 | 0.04* | 0.69 (0.50 to 0.97) |
| Cholangiocarcinoma (%) | 21 | 0.12 | 18 | 0.39 | <0.001*** | 0.31 (0.17 to 0.59) | 5 | 0.11 | 18 | 0.39 | 0.01* | 0.28 (0.10 to 0.75) |
| Alcoholic liver diseases (%) | 332 | 1.93 | 273 | 5.92 | <0.001*** | 0.31 (0.27 to 0.37) | 93 | 2.02 | 273 | 5.92 | <0.001*** | 0.33 (0.26 to 0.42) |
| Hepatitis B (%) | 39 | 0.23 | 24 | 0.52 | 0.002** | 0.43 (0.26 to 0.72) | 4 | 0.09 | 24 | 0.52 | <0.001*** | 0.17 (0.04 to 0.48) |
| Hepatitis C (%) | 171 | 1 | 73 | 1.58 | 0.001** | 0.62 (0.47 to 0.82) | 23 | 0.5 | 73 | 1.58 | <0.001*** | 0.31 (0.19 to 0.50) |
| Non-alcoholic fatty liver disease (%) | 710 | 4.13 | 199 | 4.32 | 0.61 | 0.96 (0.81 to 1.12) | 175 | 3.8 | 199 | 4.32 | 0.22 | 0.87 (0.71 to 1.08) |
| Nutrition | ||||||||||||
| Malnutrition (%) | 1745 | 10.2 | 548 | 11.9 | <0.001*** | 0.84 (0.76 to 0.93) | 422 | 9.16 | 548 | 11.9 | <0.001*** | 0.75 (0.65 to 0.85) |
*P<0.05, **p<0.01, ***p<0.001.