TABLE 3.
Experimental design used in experiment 1
| Groupb | No. of mice sacrificed in each groupa |
Total no. of mice | ||
|---|---|---|---|---|
| D-7 | D0 | W8 | ||
| Untreated | 3 | 3 | 5 | 11 |
| BpaL(100) | 5 | 5 | ||
| BDQ + PMD + OTB-658(50) | 5 + 5 | 10 | ||
| TBI-166 + BDQ + LZD(100) | 5 + 5 | 10 | ||
| TBI-166 + BDQ + OTB-658(50) | 5 + 5 | 10 | ||
| TBI-166 + BDQ + OTB-658(100) | 5 + 5 | 10 | ||
| Total no. of mice | 3 | 3 | 50 | 56 |
a
Time points: D-7 = 14 days after aerosol infection (n = 3), D0 = day of treatment, 21 days after infection (n = 3); W8 = treated for 8 weeks. D, day; W, week.
b
Drugs (abbreviations) and doses: bedaquiline (BDQ), 25 mg/kg; pretomanid (PMD), 100 mg/kg; linezolid (LZD), 100 mg/kg; TBI-166, 20 mg/kg; OTB-658(50), 50 mg/kg; OTB-658(100), 100 mg/kg; BpaL(100), BDQ + PMD + LZD(100).