TABLE 4.
Experimental design used in experiment 2
| Groupb | No. of mice sacrificed in each groupa |
Total no. of mice | |||
|---|---|---|---|---|---|
| D-11 | D0 | W4 | W8 | ||
| Untreated | 5 | 5 | 10 | ||
| BpaL(100) | 5 + 15 | 5 + 15 | 40 | ||
| TBI-166 + BDQ + LZD(100) | 5 + 15 | 5 + 15 | 40 | ||
| TBI-166 + BDQ + OTB-658(100) | 5 + 15 | 5 + 15 | 40 | ||
| Total no. of mice | 5 | 5 | 60 | 60 | 130 |
a
Time points: D-11 = 3 days after aerosol infection (n = 5), D0 = day of treatment, 14 days after infection (n = 5); W4 = treated for 4 weeks; W8 = treated for 8 weeks. D, day; W, week.
b
Drugs (abbreviations) and doses: bedaquiline (BDQ), 25 mg/kg; pretomanid (PMD), 100 mg/kg; linezolid (LZD), 100 mg/kg; TBI-166, 20 mg/kg; OTB-658, 100 mg/kg; BpaL(100), BDQ + PMD + LZD(100).