TABLE 5.
Experimental design used in experiment 3
| Groupb | No. of mice sacrificed in each groupa |
Total no. of mice | ||
|---|---|---|---|---|
| D0 | W4 | W8 | ||
| Untreated | 4 | 5 | 5 | 14 |
| TBI-166 | 5 | 5 | 10 | |
| LZD | 5 | 5 | 10 | |
| OTB-658 | 5 | 5 | 10 | |
| TBI-166 + LZD | 5 | 5 | 10 | |
| TBI-166 + OTB-658 | 5 | 5 | 10 | |
| Total no. of mice | 4 | 30 | 30 | 64 |
a
Time points: D0 = day of treatment, 10 days after infection (n = 4); W4 = treated for 4 weeks; W8 = treated for 8 weeks. D, day; W, week.
b
Drugs (abbreviations) and doses: linezolid (LZD), 100 mg/kg; TBI-166, 20 mg/kg; OTB-658, 100 mg/kg.