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. 2023 Feb 2;13:1072420. doi: 10.3389/fimmu.2022.1072420

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Copyright © 2023 Jouhault, Cherqaoui, Jobart-Malfait, Glatigny, Lauraine, Hulot, Morelle, Hagege, Ermoza, El Marjou, Izac, Saintpierre, Letourneur, Rémy, Anegon, Boissier, Chiocchia, Breban and Araujo

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IL-27 decreases IL-17 production by T cells from SpA patients. (A) Left panel: representative dot-plot and right panel: percentage of IL-17 producing-CD4⁺ T cells from SpA patients cultured during 6 days with IL-2 in the presence or absence of IL-27 and determined after PMA/ionomycin stimulation. (B) IL-17 production was measured in culture supernatants by ELISA. (C) Percentage of inhibition of IL-17 production induced by IL-27 presence in cultures of CD4+T cells from healthy controls and SpA patients. *p < 0.05 **p<0.005 ****p<0.0001/ ***p=0.001.