TABLE 1.
Selected NPP3C analogues from SAR studies
Compound | Structure | DENV-R2A replication (fold DMSO) | Cell viability (fold DMSO) |
---|---|---|---|
NPP3C |
![]() |
0.01 | 0.80 |
66 |
![]() |
1.34 | 0.88 |
7 |
![]() |
0.82 | 1.16 |
29 |
![]() |
0.99 | 0.95 |
65 |
![]() |
0.98 | 0.87 |
55 |
![]() |
0.75 | 0.96 |
52 |
![]() |
1.07 | 0.95 |
54 |
![]() |
0.37 | 0.67 |
63 |
![]() |
1.38 | 0.90 |
56 |
![]() |
1.47 | 0.94 |