Skip to main content
. 2023 Jan 17;67(2):e01276-22. doi: 10.1128/aac.01276-22

FIG 3.

FIG 3

Comparison of urinary injury biomarkers for rats in the loading dose arm, between treatment groups and across dosing days. The vancomycin no-load group was used as the comparator. (a) Significant differences in urinary KIM-1 were observed on the morning of day 1 (*, 213.9 ng/24 h [95% CI, 118.5 to 309.2 ng/24 h] [P < 0.001]) and on day 2 (#, 163.6 ng/24 h [95% CI, 68.2 to 258.9 ng/24 h] [P = 0.001]) among rats in the vancomycin load group. (b) Significant differences in urinary clusterin were observed on the morning of day 1 (†, 16,493 ng/24 h [95% CI, 6,277 to 26,710 ng/24 h] [P = 0.002]) and on day 2 (§, 13,397 ng/24 h [95% CI, 3,180 to 23,614 ng/24 h] [P = 0.01]). (c) A significant difference in urinary OPN was observed on the morning of day 1 (‡, 12.5 ng/24 h [95% CI, 6.24 to 18.7 ng/24 h] [P < 0.001]).