TABLE 1.

Marginal differences versus the VAN no-load group as a reference^a

Parameter on dosing day	Value for VAN loading dose group
Mean GFR difference (mL/min/100 g of body wt) (95% CI),  P value
Baseline	−0.01 (−0.09 to 0.07), 0.79
Day 1-AM	−0.16 (−0.24 to −0.08), <0.001
Day 1-PM	−0.12 (−0.19 to −0.04), 0.005
Day 2	−0.11 (−0.19 to −0.03), 0.007
Day 3	−0.07 (−0.15 to 0.01), 0.08
Day 4	−0.06 (−0.14 to 0.03), 0.18
Mean urinary KIM-1 difference (ng) (95% CI), P value
Baseline	1.56 (−93.8 to 96.9), 0.97
Day 1-AM	213.9 (118.5 to 309.2), <0.001
Day 1-PM	71.8 (−23.6 to 167.1), 0.14
Day 2	163.6 (68.2 to 258.9), 0.001
Day 3	50.7 (−44.6 to 146.1), 0.29
Day 4	30.0 (−65.3 to 125.4), 0.54
Mean urinary clusterin difference (ng) (95% CI), P value
Baseline	7,073 (−3,144 to 17,290), 0.18
Day 1-AM	16,493 (6,277 to 26,710), 0.002
Day 1-PM	5,106 (−5,110 to 15,323), 0.33
Day 2	13,397 (3,180 to 23,614), 0.01
Day 3	8,317 (−1,900 to 18,534), 0.11
Day 4	5,835 (−4,382 to 16,051), 0.26
Mean urinary OPN difference (ng) (95% CI), P value
Baseline	0.96 (−5.28 to 7.20), 0.76
Day 1-AM	12.5 (6.24 to 18.7), <0.001
Day 1-PM	4.72 (−1.52 to 10.9), 0.14
Day 2	3.95 (−2.29 to 10.2), 0.21
Day 3	0.57 (−5.67 to 6.81), 0.86
Day 4	−1.68 (−7.92 to 4.56), 0.60
Mean urine output difference (mL) (95% CI), P value
Baseline	3.86 (−0.07 to 7.79), 0.054
Day 1-AM	3.31 (−0.63 to 7.24), 0.09
Day 1-PM	2.13 (−1.80 to 6.06), 0.29
Day 2	3.38 (−0.55 to 7.31), 0.09
Day 3	5.11 (1.18 to 9.04), 0.01
Day 4	0.43 (−3.51 to 4.36), 0.83

^aBoldface type indicates significantly different values.