TABLE 2.
Marginal differences versus the AKI positive control (folic acid) as the reference groupa
| Parameter on dosing day | Value for treatment group |
|
|---|---|---|
| Low VAN dose | High VAN dose | |
| Mean GFR difference (mL/min/100 g of body wt) (95% CI), P value | ||
| Baseline (day 0) | 0.01 (−0.11 to 0.12), 0.86 | 0.01 (−0.10 to 0.12), 0.86 |
| Day 1 | 0.33 (0.22 to 0.44), <0.001 | 0.21 (0.09 to 0.32), <0.001 |
| Day 2 | 0.34 (0.23 to 0.45), <0.001 | 0.22 (0.11 to 0.33), <0.001 |
| Day 3 | 0.29 (0.18 to 0.40), <0.001 | 0.24 (0.13 to 0.35), <0.001 |
| Day 4 | 0.39 (0.29 to 0.51), <0.001 | 0.26 (0.15 to 0.37), <0.001 |
| Mean urinary KIM-1 difference (ng) (95% CI), P value | ||
| Baseline | 0.53 (−149.5 to 150.6), 0.99 | −1.78 (−151.8 to 148.2), 0.98 |
| Day 1 | −215.6 (−365.6 to −65.6), 0.005 | −85.0 (−235.1 to 64.9), 0.27 |
| Day 2 | −344.1 (−494.1 to −194.1), <0.001 | −149.1 (−299.1 to 0.92), 0.051 |
| Day 3 | −239.4 (−389.4 to −89.3), 0.002 | −154.4 (−304.4 to −4.33), 0.044 |
| Day 4 | −154.3 (−304.3 to −4.24), 0.044 | 43.4 (−106.8 to 193.3), 0.57 |
| Mean urinary clusterin difference (ng) (95% CI), P value | ||
| Baseline | 227 (−14,038 to 14,491), 0.98 | 339 (−13,925 to 14,603), 0.96 |
| Day 1 | −12,984 (−27,248 to 1,281), 0.07 | 47 (−14,218 to 14,311), 0.99 |
| Day 2 | −20,652 (−34,917 to −6,388), 0.005 | 5,221 (−9,044 to 19,485), 0.47 |
| Day 3 | −14,021 (−28,285 to 244), 0.054 | 2,058 (−12,207 to 16,322), 0.78 |
| Day 4 | −15,682 (−29,947 to −1,418), 0.031 | −16,037 (−31,018 to −1,057), 0.036 |
| Mean urinary OPN difference (ng) (95% CI), P value | ||
| Baseline | 0.32 (−19.6 to 20.3), 0.98 | −0.68 (−23.0 to 21.7), 0.95 |
| Day 1 | −38.5 (−54.7 to −22.2), <0.001 | −37.0 (−52.6 to −21.4), <0.001 |
| Day 2 | −52.1 (−68.4 to −35.8), <0.001 | −48.6 (−64.2 to −33.0), <0.001 |
| Day 3 | −33.9 (−51.1 to −16.7), <0.001 | −37.0 (−52.6 to −21.4), <0.001 |
| Day 4 | −57.6 (−73.2 to −42.0), <0.001 | −60.2 (−78.8 to −41.6), <0.001 |
| Mean urine output difference (mL) (95% CI), P value | ||
| Baseline | 3.7 (−1.8 to 9.2), 0.19 | 2.4 (−3.2 to 7.9), 0.39 |
| Day 1 | −2.9 (−8.4 to 2.7), 0.31 | −2.4 (−7.9 to 3.1), 0.39 |
| Day 2 | −16.1 (−21.7 to −10.6), <0.001 | −10.3 (−15.9 to −4.8), <0.001 |
| Day 3 | −10.3 (−15.8 to −4.8), <0.001 | −9.8 (−15.3 to −4.2), 0.001 |
| Day 4 | −0.9 (−6.5 to 4.6), 0.75 | −0.1 (−5.7 to 5.4), 0.97 |
a
Boldface type indicates significantly different values.