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. 2023 Feb 13;11:e14826. doi: 10.7717/peerj.14826

Figure 1. Bre decreased glomerular injury in DN mice.

Figure 1

(A) The establishment of diabetic mice model and treatment procedure. After being treated with Bre (15 or 30 mg/kg) for 4 weeks, the mice were euthanized, and renal tissues were collected for HE (B, scale bar = 100 μm), PAS (D, scale bar = 50 μm), and Masson (E, scale bar = 50 μm) staining. (C) The glomerular surface area was measured in accordance with the results of HE staining. After being treated with Bre (15 or 30 mg/kg) for 4 weeks, the mice were euthanized, and blood samples were collected to assess serum creatinine (F) and BUN (G) levels. n = 7. *p < 0.05, **p < 0.01, ***p < 0.001.