Table 2. Tissue markers measured in the liver of the studied groups by Real-time PCR analysis.
| Control | AKI | AKI+Saline | AKI+Vildagliptin | AKI+Saline+Vildagliptin | |
|---|---|---|---|---|---|
|
cFOS
(Relative Expression) |
1.013 ± 0.025 | 4.76 ± 0.332* | 2.801 ± 0.304*# | 2.583 ± 0.348*# | 1.936 ± 0.098*#@$ |
|
cJUN
(Relative Expression) |
1.028 ± 0.031 | 6.03 ± 0.135* | 3.016 ± 0.171*# | 3.11 ± 0.357*# | 2.185 ± 0.303*#@$ |
|
HMGB1
(Relative Expression) |
1.07 ± 0.04 | 5.53 ± 0.17* | 2.42 ± 0.275*# | 2.58 ± 0.35*# | 2.02 ± 0.084*#@$ |
Notes:
*
Significant compared to control at P-value ≤ 0.05.
#
Significant compared to AKI at P-value ≤ 0.05.
@
Significant compared to AKI+Saline at P-value ≤ 0.05.
$
Significant compared to AKI+Vildagliptin at P-value ≤ 0.05.
AKI, Acute Kidney Injury; TNF-α, Tumor necrotic factor-α; IL-6, interleukin-6; HMGB, High-mobility-group-box protein.