Table 2.
Serological measures before and after vaccination, between prior COVID groups
| Prior COVID | P value | |||
|---|---|---|---|---|
| Time Period | Recovered COVID* | PASC* | ||
| Log 10 IgG-S levels | ||||
| Before vaccination | 3.17 [2.35, 4.26] | 3.25 [2.62, 3.83] | 0.75 | |
| After vaccination, 0–8 weeks | 4.31 [4.10, 4.52] | 4.47 [4.35, 4.81] | 0.004 | |
| More than 8 weeks after vaccination | 3.74 [3.36, 4.08] | 3.98 [3.59, 4.45] | < 0.001 | |
| IgG-N levels | ||||
| Before vaccination | 1.42 [0.10, 3.34] | 1.46 [0.49, 3.44] | 0.13 | |
| After vaccination, 0–8 weeks | 1.43 [0.45, 2.88] | 1.86 [1.06, 3.17] | 0.09 | |
| More than 8 weeks after vaccination | 0.62 [0.19, 1.71] | 0.82 [0.32, 1.82] | 0.06 | |
| Log 10 (IgM-S + 1) levels | ||||
| Before vaccination | 0.29 [0.11, 0.56] | 0.18 [0.08, 0.42] | 0.034 | |
| After vaccination, 0–8 weeks | 0.28 [0.15, 0.55] | 0.18 [0.10, 0.24] | 0.001 | |
| More than 8 weeks after vaccination | 0.15 [0.09, 0.33] | 0.13 [0.07, 0.28] | 0.12 | |
| ACE2 Binding levels | ||||
| Before vaccination | 100.0 [98.3, 100.0] | 70.2 [14.9, 99.0] | < 0.001 | |
| After vaccination, 0–8 weeks | 100.0 [99.0, 100.0] | 100.0 [100.0, 100.0] | 0.35 | |
| More than 8 weeks after vaccination | 98.2 [90.7, 99.5] | 99.1 [89.9, 99.9] | 0.044 | |
*Values are shown as median and interquartile range [IQR], with comparisons performed using two-sided Wilcoxon tests